Contents

2.1 Abbreviations 17

2.2 Basic Concepts and Definitions 18

2.3 Enzyme Nomenclature 21

2.4 Phase I: Enzymes 21

2.5 Phase II: Enzymes 39

References 45

Additional Reading 46

2.1 ABBREVIATIONS

ABT

Aminobenzotriazole

ADH

Alcohol dehydrogenase

AKR

Aldo-keto reductase

ALDH

Aldehyde dehydrogenase

AO

Aldehyde oxidase

AZT

3' -Azido-3' -deoxythimidine

BSO

L-Buthionine-sulfoximine

CDNB

1-Chloro-2,4-dinitrobenzene

S.C. Khojasteh et al., Drug Metabolism and Pharmacokinetics 17

Quick Guide, DOI 10.1007/978-1-4419-5629-3_2, © Springer Science+Business Media, LLC 2011

CL

Clearance

DCNP

2,6-Dichloro-4-nitrophenol

DME

Drug metabolizing enzyme

EC

Enzyme classification number based on enzyme

function

EH

Epoxide hydrolase

ER

Endoplasmic reticulum (i.e., microsomes)

FAD

Flavin adenine dinucleotide

FMO

Flavin-containing monooxygenase

GI

Gastrointestinal

GST

Glutathione S-transferase

LM

Liver microsomes

MAO

Monoamine oxidase

mCPBA

m-Chloroperoxybenzoic acid

NAC

N-Acetylcysteine

NAD

Nicotinamide adenine dinucleotide

NADPH

Nicotinamide adenine dinucleotide phosphate

NAT

N-Acetyltransferase

P450

Cytochrome P450

PAPS

3'-Phosphoadenosine-5' -phosphosulfate

PM

Poor metabolizer

NQO

NADPH:quinone reductase

SAM

S-Adenosyl methionine

SULT

Sulfotransferase

UDPGA

Uridine diphosphoglucuronic acid

UGT

Uridine diphosphate glucuronosyltransferase

XDH

Xanthine dehydrogenase

XO

Xanthine oxidase

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