Pharmacological Science Drug Metabolism

3.1 List of Abbreviations 47

3.2 Basic Concepts 48

3.3 Gastrointestinal pH and Transit Times 52

3.4 Food Effects on Oral Absorption 52

3.5 Biopharmaceutics Classification System (BCS) 53

References 56

Additional Readings 56

3.1 LIST OF ABBREVIATIONS

BCS

Biopharmaceutics classification system

BDDCS

Biopharmaceutics drug disposition classification system

AUCPO

AUC following an oral dose

AUCiv

AUC following an intravenous dose

Eg

Extraction ratio of the gut

Eh

Extraction ratio of the liver

F

Bioavailability

Fa

Fraction of drug absorbed from the intestinal lumen

Fg

Fraction of orally administered drug escaping intestinal

metabolism

Fh

Fraction of orally administered drug escaping hepatic

metabolism/elimination

MAD

Maximum absorbable dose

S.C. Khojasteh et al., Drug Metabolism and Pharmacokinetics 47

Quick Guide, DOI 10.1007/978-1-4419-5629-3_3, © Springer Science+Business Media, LLC 2011

S.C. Khojasteh et al., Drug Metabolism and Pharmacokinetics 47

Quick Guide, DOI 10.1007/978-1-4419-5629-3_3, © Springer Science+Business Media, LLC 2011

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