Contents

1 Pharmacokinetics 1

2 Drug Metabolizing Enzymes 17

3 Oral Absorption 47

4 Transporters 57

5 Metabolism-Based Drug Interactions 73

6 Biotransformation and Bioactivation 97

7 Prediction of Human Pharmacokinetics 127

8 Advances in Bioanalysis as It Relates to ADME 145

9 ADME Properties and Their Dependence on Physicochemical Properties 165

10 In Silico ADME Tools 183

11 Approved Drugs 193

12 Chemical Nomenclature 201

Index 207

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