Intestine

Apical (Luminal)

INTESTINAL KPITHKLTA

Basolateral

INTESTINAL LUMEN

Apical (Luminal)

INTESTINAL KPITHKLTA

Basolateral

INTESTINAL LUMEN

BLOOD

Figure 4.1. Localization of select transporters on intestinal epithelial cells (Adapted from The International Transporter Consortium, 2010).

BLOOD

Figure 4.1. Localization of select transporters on intestinal epithelial cells (Adapted from The International Transporter Consortium, 2010).

4.4.2 Liver

Figure 4.2. Localization of select transporters on hepatocytes (Adapted from The International Transporter Consortium, 2010).

4.4.3 Kidney

Figure 4.3. Localization of select transporters on kidney proximal tubule cells (Adapted from The International Transporter Consortium, 2010).

4.4.4 Blood-Brain Barrier

Figure 4.4. Localization of select transporters on brain capillary endothelial cells (Adapted from The International Transporter Consortium, 2010).

The blood-brain barrier is unique in that the basolateral membrane of brain capillary endothelial cells face the brain rather than the blood. In the intestine, liver and kidney cells, the basolateral membrane faces the blood.

Table 4.1. Localization of select ABC transporters Transporter

(alias) Gene

Location (organs/cells)

MDR1 (P-gp, ABCB1 Intestinal enterocytes, kidney proximal

ABCB1) tubule, hepatocytes (canalicular), brain endothelia

MDR3 (ABCB4) ABCB4 Hepatocytes (canalicular)

BCRP (MXR) ABCG2 Intestinal enterocytes, hepatocytes

(canalicular), kidney proximal tubule, brain endothelia, placenta, stem cells, mammary glands (lactating) MRP2 (ABCC2, ABCC2 Hepatocytes (canalicular), kidney cMOAT) (proximal tubule, luminal), enterocytes

(luminal)

MRP3 (ABCC3) ABCC3 Hepatocytes (sinusoidal), intestinal enterocytes (basolateral) MRP4 (ABCC4) ABCC4 Kidney proximal tubule (luminal), choroid plexus, hepatocytes (sinusoidal), platelets BSEP (SPGP, ABCB11 Hepatocytes (canalicular)

cBAT, ABCB11)

Data from The International Transporter Consortium (2010)

Table 4.2. Localization of select SLC transporters

Transporter (alias)

Gene

Location (organs/cells)

OATP1A2 (OATP-A)

SLCO1A2

Brain capillaries endothelia,

cholangiocytes, distal nephron

OATP1B1 (OATP-C,

SLCO1B1

Hepatocytes (sinusoidal)

OATP2, LST-1)

OATP1B3 (OATP-8)

SLCO1B3

Hepatocytes (sinusoidal)

OATP2B1 (OATP-B)

SLCO2B1

Hepatocytes (sinusoidal), endothelia

OAT1

SLC22A6

Kidney proximal tubule, placenta

OAT3

SLC22A8

Kidney proximal tubule, choroid plexus,

blood-brain barrier

OCT1

SLC22A1

Hepatocytes (sinusoidal), intestinal

enterocytes

OCT2

SLC22A2

Kidney proximal tubule, neurons

PEPT1

SLC15A1

Intestinal enterocytes, kidney proximal

tubule

PEPT2

SLC15A2

Kidney proximal tubule, choroid plexus,

lung

MATE1

SLC47A1

Kidney proximal tubule, liver

(canalicular membrane), skeletal

muscle

MATE2-K

SLC47A2

Kidney proximal tubule

Was this article helpful?

0 0

Post a comment