Enzymes in this group are responsible for transferring a methyl group to a phenolic alcohol (such as phenol O-methyltransferase (POMT) and catechol-O-methyltransferase (COMT)), an azaheter-ocyclic nitrogen (such as N-methyltransferase), or a free thiol (such as S-methyltransferase).

Cofactor: S-adenosyl methionine (SAM). Catechol-O-Methyltransferase (COMT; EC Subcellular location: Cytosol and ER. Reaction: Transfer of a methyl group to catechols. Inhibitors: Tolcapone and entacapone.

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