Enzymes in this group are responsible for transferring a methyl group to a phenolic alcohol (such as phenol O-methyltransferase (POMT) and catechol-O-methyltransferase (COMT)), an azaheter-ocyclic nitrogen (such as N-methyltransferase), or a free thiol (such as S-methyltransferase).
Cofactor: S-adenosyl methionine (SAM).
188.8.131.52 Catechol-O-Methyltransferase (COMT; EC 184.108.40.206) Subcellular location: Cytosol and ER. Reaction: Transfer of a methyl group to catechols. Inhibitors: Tolcapone and entacapone.
Was this article helpful?