Subcellular location: Cytosol.
Organ distribution: In humans, NAT1 is widely distributed, and NAT2 (polymorphic) is present in the liver and small intestine.
Reaction: Transfer of an acetyl group from acetyl-CoA to an aromatic amine or N-hydroxylamine.
Substrates: Aminofluorene and 4-aminobiphenyl are nonselective substrates. Sulfamethazine and isoniazide are selective NAT2 substrates.
NAT2 is polymorphic and poor metabolizers (PMs) might have a higher incidence of adverse drug reactions and susceptibility to specific cancers.
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