NAcetyltransferases NATs EC 23187

Subcellular location: Cytosol.

Organ distribution: In humans, NAT1 is widely distributed, and NAT2 (polymorphic) is present in the liver and small intestine.

Cofactor: Acetyl-CoA.

Reaction: Transfer of an acetyl group from acetyl-CoA to an aromatic amine or N-hydroxylamine.

Substrates: Aminofluorene and 4-aminobiphenyl are nonselective substrates. Sulfamethazine and isoniazide are selective NAT2 substrates.

NAT2 is polymorphic and poor metabolizers (PMs) might have a higher incidence of adverse drug reactions and susceptibility to specific cancers.

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