One Compartment Model

Compounds exhibiting kinetics described by a one-compartment model have a log concentration-time profile that is monophasic in nature (see Fig. 1.5).

1.3 COMPARTMENTAL MODELING 9

1.3.1.1 Intravenous Dosing k - first-order elimination rate constant (units of time-1)

IV Dose

IV Dose

Figure 1.5. One-compartment model following a single intravenous dose.

Concentration following an intravenous dose can be calculated using the following equation:

where

C is concentration

CinitiaL is the initial concentration following IV dosing k is the first-order elimination rate constant t is time

1.3.1.2 Extravascular Dosing k - first-order elimination rate constant (units of time-1) ka - first-order absorption rate constant (units of time-1)

Figure 1.6. One-compartment model following a single extravascular dose.

Concentration following an extravascular dose (see Fig. 1.6) can be calculated using the following equation:

where

C is the concentration

F is bioavailability

Vd is volume of distribution ka is first-order absorption rate constant k is first-order elimination rate constant t is time

Was this article helpful?

0 0

Post a comment