Compounds exhibiting kinetics described by a one-compartment model have a log concentration-time profile that is monophasic in nature (see Fig. 1.5).
1.3 COMPARTMENTAL MODELING 9
1.3.1.1 Intravenous Dosing k - first-order elimination rate constant (units of time-1)
IV Dose
IV Dose
Concentration following an intravenous dose can be calculated using the following equation:
where
C is concentration
CinitiaL is the initial concentration following IV dosing k is the first-order elimination rate constant t is time
1.3.1.2 Extravascular Dosing k - first-order elimination rate constant (units of time-1) ka - first-order absorption rate constant (units of time-1)
Concentration following an extravascular dose (see Fig. 1.6) can be calculated using the following equation:
where
C is the concentration
F is bioavailability
Vd is volume of distribution ka is first-order absorption rate constant k is first-order elimination rate constant t is time
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