Subcellular location: Cytosol. Organ distribution: Liver and small intestine. Cofactor: 3'-Phosphoadenosine-5'-phosphosulfate (PAPS). Reaction: Transfer of sulfonate (SO3~) to an alcohol, amine, or hydroxylamine on the substrate.
Isoforms: SuLT1A1 (expressed in the liver) conjugates small planar phenols, and SuLT1A3 conjugates catecholamines. Inhibitor: 2,6-Dichloro-4-nitrophenol (DCNP). Substrates: Acetaminophen, minoxidil, and tamoxifen.
SULTs typically have higher affinities for substrates than UGTs do, and therefore, SULTs are saturated at lower substrate concentrations.
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