VuTy

where

Vp is the volume of plasma VT is the volume of tissue fu is the unbound fraction in plasma fuT is the unbound fraction in tissue

The tissue volume is influenced by the degree of protein and tissue binding. For example, an increase in protein binding in the absence of tissue binding changes will cause a decrease in fu and a decrease in the volume of distribution.

For a compound exhibiting one compartment characteristics

where VSS is the volume of distribution at steady state and VC is the volume of the central compartment.

For compounds showing multiple compartment characteristics (see Fig. 1.3)

Vd(Vb for a 2 - compartment model) > VSS > VC (1.10)

Figure 1.3. Concentration-time profile showing derivation of Cinitiai and b.

Figure 1.3. Concentration-time profile showing derivation of Cinitiai and b.

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