3D Dn2

m h2

X exp

The burst time tB is defined as the intercept of Qt on the t axis:

For an ideal membrane, tL and tB emphasize the path length and the diffusion constant. Binding and heterogeneity of the membrane may complicate these simple relationships. In practice, as shown in Fig. 4.2, membrane reservoir systems have a period of constant release, i.e., steady-

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