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Both treatments assume that the dissolution of drug is rapid compared with the diffusion of drug, and both predict release of drug that is linear with This is a consequence of the increased diffusional distance and decreased diffusional area at the diffusion front as drug release proceeds. Figure 4.1 illustrates the amount released Qt versus square-root-time V? plots for two cases: both dispersed (loading greater than saturation,

A/Cs =

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