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Polymer diffusion

Diffusion of drug molecules

Polymer diffusion

Diffusion of drug molecules

Water penetration

Figure 4.4 "Spaghetti" model for a swollen matrix.

contribution of polymer diffusion/dissolution, whereas solubility of drug molecules defines the diffusion component. The impact of formulation is largely reflected through an equivalent Cp,dis. These parameters are defined as

MWpXp 96,000

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