O

Figure 3.11 Tenofovir (a) and tenofovir disoproxil fumarate (b).

TABLE 3.4 Examples of Salt Prodrugs

General design objective

Goal

Drug

Prodrug

Improvement of

Increase solubility

Phenytoin

Fosphenytoin47

physicochemical

Increase solubility

Amprenavir

Fosamprenavir

properties

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