Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location. Currently, many drug delivery systems are available for delivering drugs with either time or spatial controls, and numerous others are under investigation. Many books and reviews on drug delivery systems based on drug release mechanism(s) have been published. As the technology evolves, it is crucial to introduce these new drug delivery concepts in a logical way with successful examples, so that the pharmaceutical scientists and engineers working in the fields of drug discovery, development, and bioengineering can grasp and apply them easily.

In this book, drug delivery systems are presented with emphases on the design principles and their physiological/pathological basis. The content in each chapter is organized with the following sections:

■ Introduction

■ Rationale for the system design

■ Mechanism or kinetics of controlled release

■ Key parameters that can be used to modulate the drug delivery rate or spatial targeting

■ Current status of the system/technology

■ Future potential of the delivery system

Prior to discussing individual drug delivery system/technology based on the design principles, the basic concepts of pharmacokinetics and biological barriers to drug delivery are outlined in the first two chapters.

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For each specific design principle, the contributors also briefly introduce the relevant pharmacokinetics (where necessary) and include the challenges of different biological barriers that need to be overcome.

It is our belief that this book provides distinctive knowledge to pharmaceutical scientists, bioengineers, and graduate students in the related fields and can serve as a comprehensive guide and reference to their research and study.

We would like to thank all the authors for their contributions to this book project. Especially, we would like to thank Mr. Kenneth McCombs at McGraw-Hill for his patience, understanding, and support in editing this book.

Xiaoling Li, Ph.D.

BhaskaraR. Jasti, Ph.D.

Department of Pharmaceutics and Medicinal Chemistry Thomas J. Long School of Pharmacy and Health Sciences

University of the Pacific Stockton, California

Design of Controlled Release Drug Delivery Systems

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