o CH

Figure 3.3 Piroxicam (a) and ampiroxicam (b).

to the presence of two strongly basic groups and a carboxylic acid group causing the compound to exist as a zwitterion at intestinal pH. The resulting prodrug, ximelagatran, is uncharged at intestinal pH and has 80-fold improved permeability and an oral bioavailability of 20 percent.

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