Cyp2d6

ProzacĀ® (fluoxetine)

Adverse reaction

Comment

Reference

Bleeding

Bleeding

Phenytoin toxicity

Phenytoin toxicity

Phenytoin toxicity

H. pylori eradication rate reduced in 2C19 extensive metabolizers

Seizures, cardiac arrest, and death

Reduced dose associated with 13

variant CYP2C9 alleles Low dose requirement of 14

acenocoumarol associated with a *3 allele Raised drug levels associated 15

with *2 and *3 alleles Associated with *3 16

homozygosity and CYP2C19*2 heterozygosity Association of fluoxamine with 17 CYP2C9 and CYP2C19 wild-type alleles attributed to drug interaction

Reduced eradication rate 18

attributed to homozygous (72.7%) and heterozygous (92.1%) extensive metabolizers compared to poor metabolizers (97.8%)

Toxicity and death associated 19 with CYP2D6 poor metabolizer genotype

Codeine

33-y/o woman

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