Drug Target Discovery by Receptorome Screening

The receptorome encodes receptors that mediate responses to a large number of exogenous and endogenous substances, including the majority of medications used in the treatment of human disease.136,137 It comprises at least 5% of the human genome. Screening the receptorome has been used as an efficient approach to drug target validation and discovery of new therapeutic drugs. Receptor screening has also been used to discover the molecular targets for serious drug side effects as the ''fen-phen'' story described below illustrates.

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