Ethnic Specificity In Drug Development

The ultimate purpose of pharmacogenetic investigation is to gather information that provides clues to the basis for an unexpected drug response and enables the expression of a given trait in susceptible persons to be avoided or managed safely and effectively. In essence, the genetics (mode of inheritance, allelic frequencies, ethnic and geographic specificities) and molecular basis (genes responsible and their mutation spectrum) constitute the information that characterizes a given pharmacogenetic trait. Clearly, information on ethnogeographic variations in response of individuals contributes to these categories of information and lacking such global information could severely compromise efforts to optimize the development and clinical testing of new drugs.

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