Evidence For Individual Variation In Drug Response

Most pharmacologically relevant genetic variants result in dramatic differences in gene product function or expression (complete loss of function, substantial increase in expression, etc). As a consequence, they have a major effect on the pharmacokinetic or pharmacodynamic properties of a drug. This is illustrated by

DIB U CAI NE NU H U LU PLASMA ISONIAZIO CONCENTRATION (us/nll

TPHT ACTIVITE (umts/ml RBC)

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