Hardy Weinberg Tests of Pharmacogenetic Hypotheses

Sampling a population whose members differ quantitatively or qualitatively is a situation that arises whenever heterogeneity in individual drug responses is investigated. Studies making use of the Hardy-Weinberg law were performed in the 1930s on phenylthiourea taste testing and in the 1950s on isoniazid acety-lation, succinylcholine sensitivity, and G6PD deficiency (see Chapter 1). These are excellent models to illustrate the application of the statistical principles embodied in the Hardy-Weinberg law to the interpretation of pharmacogenetic data. Applications of this principle to an autosomal recessive trait (isoniazid acetylation polymorphism) and a sex-(X)-linked trait (G6PD deficiency) are illustrated below.

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