Figure 5.8 Checkerboard diagram showing the segregation of gene-controlling isoniazid acetylation giving genotypes of Japanese parents and offspring.

transmission quantitatively by comparing the numbers of female reactors and male reactors observed in the random populations with the expected numbers; sex-linked recessive inheritance is distinguished from the other modes of inheritance by the fact that the expected frequency of female reactors is given by the square of the expected frequency of male reactors. The data were found to fit this hypothesis (see Table 5.12).

Many years later, the gene that encodes G6PD was shown to be located on the long arm of chromosome Xq28 between the genes for factor VIII and for color

10 20 30 40 SO 60 70 80 90 100 10 20 30 40 SO 60 70 80 90 100

Post-incubation glutathione values

Figure 5.9 Distribution of postincubation glutathione stability values among males and females.

Table 5.12 The Distribution of Glutathione Stability Values among Randomly Selected Negro Males and Females35



Expected frequency

Observed occurrence



Females Normal Intermediate Reactor Total

Males Normal Intermediate Reactor Total

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