repair genes is a common event in cancer progression 9 including cancers of hematological origin.129-131 Methylation of CpG islands located in promoter regions of cancer cell genes and conformational changes in chromatin involving histone acetylation are two processes that are associated with transcriptional silencing (Figure 6.6). Reversal of these processes and upregulation of genes important in preventing or reversing the malignant phenotype have thus become therapeutic targets in cancer treatment.132

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