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10 15 20 25 30 REOUCTION or PROTHROMBIN ACTIVITY (X) PRESSURE CHANGE IN 4 WEEKS [mm Ha)

Figure 2.3 Frequency distributions for genetically heterogeneous drug responder populations. (A) Succinylcholinesensitivity: dibucaine number; (B) acetylation (NAT2 polymorphism: plasma isoniazid concentrations; (C) TPMT deficiency: TPMT activity in red blood cells; (D) CYP2D6 polymorphism: dextromethorphan/dextrorphan metabolic ratio; (E) warfarin resistance: reduction of prothrombin-complex activity after a single dose of warfarin; (F) steroid-induced glaucoma: applanation pressure change in 4 weeks after intraocular administration of dexamethasone.

the bimodal and trimodal frequency distributions of drug response phenotypes in populations as shown in Figure 2.3.

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