Info

Factor V Leiden 1994 (APC resistance)

Functional-candidate gene

Gene association

Used probes from a previously 25 cloned animal (chicken) cVDR to screen a human library to identify the gene

Used probes from a previously 26 cloned human GR to isolate an AR clone from a human prostate library to identify the gene

Used probes from a previously 27 cloned animal (rabbit) cDNA to identify the human gene that had been previously assigned to human chromosome 11p to identify the gene

Used probes from a previously 28-30 cloned rat K+ channels complemented by data on linkage to the ras-1 locus on chromosome 11 to identify the K+ channel gene

Lolait et al. used a probe 31, 32

from a previously cloned rat V1a receptor for homology screening of rat kidney cDNA to identify the rat AVPR2. Birnbaumer et al. constructed a cDNA library from transformed cells expressing the ADH receptor; they probed this library with a BamHI restriction fragment (known to contain the human V2R gene) to identify the gene

Used previously cloned rat 33

and bovine AT1 cDNA sequences for homology screening of human total adrenal RNA to identify the AT II gene

Used probes from the region 34-37 of previously cloned human Factor V that contained the APC cleavage site

Gene cloned

Year

Cloning method

Strategy to identify the human gene

References b

Sulfonylurea 1995 Functional-candidate gene

Used V8 protease peptides from the N-terminal sequence of the purified hamster sulfonylurea receptor to design primers to probe a random human cDNA library

0 0

Post a comment