Deficiencies in

Prader-Willi and

106, 107

syndrome (PWS)

sexual development and growth, behavioral and mental retardation; major diagnostic criteria: hypotonia, hyperphagia and obesity, hypogonadism and developmental delay

Angelman syndromes (AS) neurogenetic disorders caused by loss of function of imprinted genes at chromosome 15q11-q13; approximately 70% of PWS and AS individuals have a 3-4 megabase deletion in their maternal or paternal chromosome 15q11-q13

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