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Figure 4.2 Effect of plasma protein binding on the relative rate of elimination of drugs excreted by glomerular filtration by newborn infants and adults.

0 20 40 60 80 100

Protein binding (% bound)

Figure 4.2 Effect of plasma protein binding on the relative rate of elimination of drugs excreted by glomerular filtration by newborn infants and adults.

Table 4.6 The Potential Effect of Plasma Protein Binding on Drug Plasma Levels and Time of Drug Elimination in Newborns versus Adults after Repeated Dosing of Drugs Excreted by Glomerular Filtration3

Drug distributed in

Plasma water Extracellular water Total body water

Plasma protein binding (% bound)

t1/2

Max blood level

F0

Variation

t1/2

Max blood level

F0

Variation

t1/2

Max blood level

F0

Variation

0 0

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