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aSource: Adapted from Sunahara et al.33

^Calculated assuming a frequency p — H0.115 — 0.3366 for the slow acetylator allele and q — 1 — 0.3366 — 0.6634 for the rapid acetylator allele.

aSource: Adapted from Sunahara et al.33

^Calculated assuming a frequency p — H0.115 — 0.3366 for the slow acetylator allele and q — 1 — 0.3366 — 0.6634 for the rapid acetylator allele.

glutathione stability test, which permitted the drug-sensitive red cell to be identified in vitro.34,35 With this test, the distributions of glutathione stability of red cells were determined for 144 male and 184 female black subjects (Figure 5.9) and in black families.36 These studies revealed two phenotypes among the males (normals and reactors) and three phenotypes among the females (normals, intermediates, and reactors). Family studies showed that transmission of the trait from father to son did not occur.

This pattern of responses suggested a sex-(X)-linked recessive mode of inheritance of the red cell sensitivity. With the aid of the Hardy-Weinberg law, Barton Childs and co-workers tested the hypothesis of sex-linked recessive

Table 5.11 Expected Numbers of Children of Each Acetylator Genotype Compared with Those Observed in 78 Japanese Matings3'6

Number of children of each genotype

Rapid Intermediate Slow Phenotypic Number of Number of - - -

Table 5.11 Expected Numbers of Children of Each Acetylator Genotype Compared with Those Observed in 78 Japanese Matings3'6

Number of children of each genotype

Rapid Intermediate Slow Phenotypic Number of Number of - - -

matingsc

matings

children

Exp

Obs

Exp

Obs

Exp

Obs

Sx S

0 0

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