Linking Pharmacogenetics To Clinical Applications Pharmacogenetics in Drug Interactions

When two or more drugs are given that are metabolized by the same enzyme they will compete with each other for that enzyme. If the enzyme is present in sufficient amount or high enough activity, no additional problems from the drug

Trait caused by 4 alleles

Candidate gene strategy

Two candidate genes

Gene association strategy High density SNP map ' ' ' 1 1 ' ' ' ' 1 1 1

Association study All 4 genes found a_A

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