ethnic specificity of, 240 in fetal tissues, 80 NAT2

development of, 80

ethnic differences in, 26

ethnic specificity of, 240

longevity and, 80

mouse models for, 273-76

polymorphism frequency distribution, 24f,

238-40, 239/ variants of, 23 NATs. See N-acetyltransferase neuroleptics, CYP2D6 and, 35, 240 neurotransmitters, drugs and development of, 91 NOAEL. See no observed adverse effect level non-drug-metabolizing enzymes, importance in pharmacogenetics, 27 no observed adverse effect level (NOAEL), establishment of, 58-59 northern blot analysis, development of, 185, 186t nortriptyline, twin studies of, 109 nuclear DNA, 101

DNA methylation of, 145-46 nuclear genome, 101-3 nucleic acids, sequencing and scanning techniques, 10-12, 11t

''odor blindness,'' identification of, 6-8 OLA. See Oligonucleotide ligation assay oligonucleotide-based microarray hypermethylation analysis with, 163 scanning and reference-based sequence checking on, 192-93

Oligonucleotide ligation assay (OLA), for scoring known mutations, 196 OMIM. See Online Mendelian Inheritance in Man

Online Mendelian Inheritance in Man (OMIM), contents of, 339 opiates, G6PD deficiency and, 246

Was this article helpful?

0 0

Post a comment