Other Recent Receptorome Based Discoveries

Receptorome screening of salvinorum A, a naturally occurring potent hallucinogen from the sage Salvia divinorum, revealed this compound has high affinity and is a potent agonist of the k opioid receptor. This interaction is specific as salvinorum A does not have appreciable activity for either m or 8 opioid receptors, and unlike lysergic acid diethylamide (LSD), salvinorum A has no activity for the 5-HT2A receptor, which is associated with hallucinations and psychosis. Another recent receptorome screening study investigating the inhibition of human poly-omavirus (JCV) infection by antipsychotics, highlighted the role of receptors in disease. The infection of oligodendrocytes by JCV results in neuronal demye-lination, which is responsible for the fatal disease progressive multifocal leu-kencephalopathy (PML). Antipsychotic drugs such as clonazipine inhibit JCV infection suggesting that one of several receptors having affinity for such drugs might participate in this process. Receptorome screening plus additional experiments pointed to a subclass of serotonin receptors that helps internalize JCV as being in part responsible for the clonazipine-related inhibitory effect.136

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