Pharmacokinetics In Pharmacogenetics

A fundamental premise of pharmacology holds that a drug must be present at receptor sites to produce its responses. For a drug that binds reversibly to its receptor, the magnitude and characteristics of its responses are directly dependent on the concentration of complexes between the drug and the receptor, and the concentration of these complexes, in turn, depends on the concentration of the

Table 3.1 The Relation of Percent Response, Normal Equivalent Deviate, and the Probits for Normally Distributed Data

Percent response

Normal equivalent deviate


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