Population Studies

Frequencies of phenotypes and genotypes that characterize a trait in populations at large are determined from studies of biologically unrelated persons by plotting the frequency distribution of the response. Ethnogeographic variation is regarded as an important facet of any comprehensive pharmacogenetic study. Ethnic differences for some human drug metabolizing enzymes are shown in the following.

Ethnic differences in

human drug metabolizing enzymes

Trait

Population frequency (%)

CYP2C19 PMs

Caucasian (4%)

CYP2C19 PMs

Asian (13-23%)

CYP2D6 PMs

Caucasian (5-10%)

CYP2D6 PMs

Japanese (<1%)

CYP2D6(L)URMs

Swedish (1-2%)

CYP2D6(L)URMs

Hispanic (7%)

CYP2D6(L)URMs

Zimbabwean (13%)

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