Sex-linked inheritance effectively means X-linked inheritance since no male (Y)-linked pharmacogenetic traits have been identified. A sex-(X)-linked dominant trait appears in every generation without skipping and with more affected females than affected males. One or both parents are affected. Affected heterozygous females transmit the trait to half of their children of either sex and affected homozygous females transmit the trait to all of their children. Notice that the pattern of transmission of a sex-linked dominant trait by females is indistinguishable from that of autosomal dominant transmission (Table 5.5).
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