The Genetic Profile Of Human Drug Response

Responses that we associate with a particular drug are actually due to physiological and biochemical properties of cells targeted by receptors of the recipient. They are determined by interactions between physiological, pathophysiological, environmental, and genetic factors. Patient physiology, pathophysiology, and environment are usually considered when prescribing a drug, but genetic variation, which may be the single most significant contributor to the drug effectiveness and toxicity, is often given short shrift.

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