Frizzled Ligands

As mentioned above, WNTs were well-known before FZDs were identified as their receptors. With the establishment of the WNT receptor concept, the development of tools such as recombinant FZD-CRDs, and the discovery of the endogenous soluble FZD-like proteins (sFRPs), led to identification of a series of FZD-interacting proteins that were capable of regulating FZD activity and WNTimediated effects i9, 18] . Most strikingly, Rispondin i 19] and Norrin [20] were identified as selective FZD ligands interacting with the CRD and mediating intracellular signaling.

0 0

Post a comment