Future Perspectives

The complexity of GPCR signaling and the potential for them to form homo-and heterodimeric structures that interact with heterotrimeric G proteins and other signaling proteins in different stoichiometric complexes within the same cells means that we need to give greater consideration to the temporal and spatial aspects ligand-receptor interactions. The recent development of fluorescent agonists and antagonists alongside high-resolution confocal imaging techniques and biophysical approaches (e.g., [152-154]) may provide the stimulus for significant progress in this area.

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