Chemical Barrier

The intact stratum corneum also acts as a barrier to chemicals brought into contact with it. Its diffusional resistance is orders of magnitude greater than that found in other barrier membranes of the body. Externally contacted chemicals can, in principle, bypass the stratum corneum by diffusing through the ducts of the appendages. The ability of each chemical to breach the skin and the diffusional route or routes it takes are dependent on its own physicochemical properties and the interactions it has within the skin's various conduit regimes. Being central to the effectiveness of dermatological products, exposition of the skin's barrier properties is made in the following sections.

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