40, 60s

¿3 hr to deaden tissue 10 (contains 1 g EMLA cream)

""Strengths" are based on delivery rates which are, in turn, proportional to the area of the patch. This can be seen upon comparing the information in column 3 with that in column 5. bIf no size is given in the current package insert, the size is "unspecified." Areas relate to the brand name products listed in column 2. In some cases, the areas given are "active areas" and do not include the additional area of a ring of peripheral adhesive.

°The strengths here may be expressed in jxg/day and, in this unit, are 25, 37.5, 50, and 75 jxg/day. dThe number is the drug loading in patches.

eDose rates for fentanyl are usually expressed in units of g/hr and range from 25 to 100 |ig/hr (0.6-2.4 mg/day). fThis is a patient-controlled iontophoretic transdermal system.

£The products in this category vary widely in dosing rate. Habitrol, Nicoderm, and generic offer patches that deliver 7, 14, and 21 mg/day; Nicotrol is a one-strength patch at 15 mg in 16 hours. ProStep provides patches that deliver 11 and 22 mg/day. In many cases, patches may not be worn at night (while in bed).

""These strengths amount to delivery rates of 0.1, 0.2,0.3,0.4,0.6 mg/hr, respectively. Nitroglycerine patches are put on in the morning and taken off in the evening and therefore worn for 12 to 14 hours. The 10- to 12-hour hiatus in dosing, the so-called washout period, is necessary to reactivate enzymes that convert nitroglycerine to its active nitrous oxide (NO) metabolite. 'Testoderm TTS is applied to body skin, while Testoderm forms are applied to scrotal skin only. JOne Testoderm scrotal form comes with an adhering surface (adhesive).

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