Source: From Refs. 2 and 10.

Source: From Refs. 2 and 10.

Formation of keratinized structures Antigen presentation Pigment synthesis Migrant cells, immune responses

Fiber synthesis

Making of ground substance, histamine

Formation of blood vessels Sensors the dermis. The dermis is also penetrated by sensory nerve endings (pressure, temperature, and pain) and houses an extensive lymphatic network. Fibroblasts, cells that synthesize the structural fibers, are found here (2), and one also finds mast cells scattered about (Table 2). The latter are thought to synthesize the ground substance. They are known to be a source of histamine that is released when the skin is immunologically provoked.

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