Unique Physicochemical Systems Used Topically

As one scans the products at the drug counter, one finds an enormous variety of formulation types available for topical therapy or for cosmetic purposes. Solutions are commonly found. They come in packages that allow them to be rubbed on, sprayed on by aerosol and atomizers, painted on, rolled on, swabbed on by premoistened pledgets, and dabbed on from applicators. Assorted medicated soaps are available for a range of purposes. Emulsions for the skin are found in the form of shampoos and as medicated lotions. Powders to soothe and lubricate are placed in sprinkling cans, while others containing drugs are formulated into aerosols to be sprayed on the skin. There are numerous fluid suspensions to be used as makeup or for therapeutic purposes. Clear and opaque gels are also to be found in both cosmetic and therapeutic spheres as are assorted semisolid creams, ointments, and pastes. The physical natures of these latter systems range from soft semisolids that are squeezed out of tubes to hardened systems suitable for application in stick form. There are therapeutic and cosmetic oils for the bath. The list of products and formulation types is nearly endless.

Of all these formulations, it is the diverse semisolids that stand out as being uniquely topical. Semisolid systems fulfill a special topical need as they cling to the surface of the skin to which they are applied, generally until being washed off or worn off. In contrast, fluid systems have poor substantivity and readily streak and run off the desired area. Similarly, powders have poor staying properties. Importantly, the fundamental physicochemical characteristics of solutions, liquid emulsions and suspensions, and powders are independent of their route of application, which are discussed adequately elsewhere in this text and need not be reconsidered. This is not to say the compositions of such systems cannot be uniquely topical, for there are chemicals that can be safely applied to the skin but are unsafe to use systemically]. There is need to elaborate the properties of semisolids.

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