The present study clearly showed that BMSCs significantly improved DAI-induced cognitive function when transplanted into the injured brain at 10 days postinjury, and the study also showed that the transplanted BMSCs could migrate widely into the brain, survive for at least 5 months, and gradually acquire the phenotypes of neural cells, especially neurons. Based on these observations, it seems that the intracerebral transplantation of BMSCs may serve as a novel therapeutic strategy for post-traumatic cognitive impairment.

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