1. Gray NS (2006) Drug discovery through industry-academic partnerships. Nature Chem Biol 2: 643-649

2. Cavalla D (2003) The extended pharmaceutical enterprise. Drug Discov Today 8: 267-274

3. Martin YC, Critchlow RE (1999) Beyond mere diversity: tailoring combinatorial libraries for drug discovery. J Comb Chem 1: 32-45

4. Burrill & Company (2008) Analysis for pharmaceutical research and manufacturers of America

5. Hughes B (2009) 2008 FDA Drug approvals. Nat Rev Drug Discov 8: 93-96

6. Ganesan A (2008) The impact of natural products upon modern drug discovery. Curr Opin Chem Biol 12: 306-317

7. Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66: 1022-1037

8. Newman DJ, Cragg GM (2005) The discovery of anticancer drugs from natural sources. In: Zhang L, Demain AL (eds) Natural products. Humana, Totowa, NJ, pp 129-168

9. Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 Years. J Nat Prod 70: 461-477

10. Butler MS, Newman DJ (2008) Mother nature's gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery. Prog Drug Res 65: 3-44

11. Feher M, Schmidt JM (2003) Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci 43: 218-227

12. Newman DJ (2008) Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J Med Chem 51: 2589-2599

13. Ganesan A (2004) Natural products as a hunting ground for combinatorial chemistry. Curr Opin Biotechnol 15: 584-590

14. Bruckdorfer T, Marder O, Albericio F (2004) From production of peptides in milligram amounts for research to multi-tons quantities for drugs of the future. Curr Pharm Biotechnol 5: 29-43

15. Sehgal A (2006) New applications in discovery, manufacturing, and therapeutics. In: Research and markets. Dublin, Ireland

16. Ayoub M, Scheidegger D (2006) Peptide drugs, overcoming the challenges, a growing business. Chem Today 24: 46-48

17. Zompra AZ, Galanis AS, Werbitzky O et al (2009) Manufacturing peptides as active pharmaceutical ingredients (API). Future Med Chem 1: 361-377

18. Hill RA (2008) Marine natural products. Ann Rep Prog Chem, Section B: Organic Chem, 104: 127-141

19. Simmons TL, Andrianasolo E, McPhail K et al (2005) Marine natural products as anticancer drugs. Mol Cancer Ther 4: 333-342

20. Bowling JJ, Kochanowska AJ, Kasanah N et al (2007) Nature's bounty—drug discovery from the sea. Exp Op Drug Disc 2: 1505-1522

21. Fusetami M (ed) (2000) Drugs from the sea. S Karger, Berlin

22. Molinski TF, Dalisay DS, Lievens SL et al (2009) Drug development from marine natural products. Nat Rev Drug Discov 8: 69-85

23. López-Macia A, Jiménez JC, Royo M et al (2001) Synthesis and structural determination of Kahalalide F. J Am Chem Soc 123: 11398-11401

24. Jou G, González I, Albericio F et al (1997) New syntheses of the didemnins: total synthesis of dehydrodidemnin B based upon two novel routes to didemnin A. Use of uronium and phosphonium salt coupling reagent in peptide synthesis in solution. J Org Chem 62: 354-366

25. Romero F, Espliego F, Perez Baz J et al (1997) Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities. J Antibiot 50: 734-737

26. Erba E, Bergamaschi D, Ronzoni S et al (1999) Mode of action of thiocoraline, a natural marine compound with anti-tumor activity. Br J Cancer 80: 971-980

27. Bayó N, Fernández A, Riego E, et al (2006) Solid-phase syntheses of azathiocoralines. Chem Eur J 12: 9001-9009

28. Tulla-Puche J, Bayó-Puxan N, Moreno JA et al (2007) Solid-phase synthesis of oxathiocora-line by a key intermolecular disulfide dimer. J Am Chem Soc 129: 5322-5323

29. Tulla-Puche J, Marcucci E, Bayó-Puxan N et al (2009) N-Me amide as synthetic surrogate for the thioester moiety in thiocoraline. J Med Chem 52: 834-839

30. Pla D, Albericio F, Alvarez M (2008) Recent advances in lamellarin alkaloids: isolation, synthesis and activity. Anti-Cancer Agents Med Chem 8: 746-760

31. Facompré M, Tardy C, Bal-Mahieu C et al (2003) Lamellarin D: a novel potent inhibitor of topoisomerase I. Cancer Res 63: 7392-7399

32. Vanhuyse M, Kluza J, Tardy C et al (2005) Lamellarin D: a novel pro-apoptotic agent from marine origin insensitive to P-glycoprotein-mediated drug efflux. Cancer Lett 221: 165-175

33. Pla D, Marchal A, Olsen CA et al (2005) Modular total synthesis of lamellarin D. J Org Chem 70: 8231-8234

34. Pla D, Marchal A, Olsen CA et al (2006) Synthesis and structure-activity relationship study of potent cytotoxic analogues of the marine alkaloid lamellarin D. J Med Chem 49: 3257-3268

35. Pla D, Francesch A, Calvo P et al (2009) Lamellarin D Bioconjugates I: Synthesis and cellular internalization of PEG-derivatives. Bioconjugate Chem 20: 1100-1111

36. Pla D, Martí M, Farrera-Sinfreu J et al (2009) Lamellarin D bioconjugates II: Synthesis and cellular internalization of dendrimer and nuclear location signal derivatives. Bioconjug Chem 20:1112-1121

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment