Clinical Consequences of the Effects of Interferons on the CYP450 System

The aforementioned studies provide some evidence that type I IFNs may inhibit or induce hepatic drug metabolism in humans and there may be some potential of toxic drug-drug interactions. However, the studies also indicate that inhibition or induction may not be of any clinical significance mainly because of the high variability and bidirectionality (inhibition in some subjects and induction in some). Because of limited number of interaction studies and since these studies were only short-term studies, it is very difficult to make an outright conclusion about the clinical consequences of these studies.

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