Effect Of Patient Variability On Exposure

Therapeutic peptides and proteins are eliminated from the body by normal physiological pathways that govern the breakdown of endogenous proteins. Low-molecular-weight proteins are subject to glomerular filtration, which can be reduced by modifications that increase size, such as pegylation or conjugation to larger proteins such as albumin. The PK behavior of larger protein drugs is dependent on target characteristics, specific interactions with receptors, including Fc receptors (FcR), and the actions of proteases within blood and tissue microenvironments. Variations in certain genes involved in these mechanisms may influence the rate of elimination.

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