Effect Of Type I Interferons On The Cyp450 System

IFN-a and IFN-b are considered type I IFNs and belong to the larger helical cytokine superfamily that includes GHs, ILs, several colony-stimulating factors, and several other regulatory molecules. Type I IFNs help the immune response by inhibiting viral replication within cells of the body; these proteins are mainly metabolized in the liver and kidneys. Since type I IFNs can affect the CYP450 system, a wide variety of interaction studies with proteins of this class have been conducted. The following are some examples of type I IFN's impact on the CYP450 system and on drug interactions.

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