FGF19 as a Target for Colorectal Cancer Treatment

FGF19 normally regulates bile acid homeostasis and gall bladder filling (110); however, therapeutic inactivation of FGF19 could be beneficial for the treatment of colon and liver cancer. FGF19 and its cognate receptor FGFR4 were found to be coexpressed in primary human liver, lung, and colon tumors (111). Desnoyers et al. related in vitro binding, phosphorylation, and cell migration of an anti-FGF19 Ab to inhibition of colon cancer xenografts in vivo (111). This Ab abolished FGF19-mediated activity in vitro, inhibited growth of colon tumor xenografts in vivo, and effectively prevented hepatocellular carcinomas in FGF19 transgenic mice (111).

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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