Heparin Aspirin and YM337

Graff et al. (51) investigated the pharmacodynamic effect of unfractionated heparin and aspirin on YM337, a Fab fragment humanized monoclonal antibody of the platelet GP IIb/IIIa receptor. Eighteen healthy male volunteers between 18 and 40 years of age were enrolled in the study. Each volunteer also received 325 mg aspirin or matching placebo for three days. The pharmacodynamic effects measured were bleeding time, expression of the platelet secretion marker CD62, and ADP (20 pM) as well as collagen (5 mg/mL) induced platelet aggregation. The results of this study indicated that unfractionated heparin and YM337 have strong synergistic effects on bleeding time, whereas coadministration of aspirin has strong inhibitory effects of YM337 on collagen-induced platelet aggregation.

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