Mechanism of Type I Interferon Inhibition of CYP450 System

The mechanism by which type I IFNs inhibit the CYP450 system is not well understood. It has been postulated that increased degradation of CYP450 apo-protein may be the reason for depressed enzymatic activity (28). It is also possible that type I IFNs increased the synthesis of xanthine oxidase, which in turn produces superoxide that destroys CYP450 (29). Some investigators (30-32) have suggested that high antiviral or antitumor activity of these IFNs through the biochemical pathways that mediate these effects may depress the CYP450 system.

0 0

Post a comment