Model

t = 0 - w < x < +w [F] = [F]0 [FH] =0 [H] = 0

dx2 Dx2

-iffl+1

dt Dt

DeiiDt\mrn+1 . fi . 2DeffDtVT-1m+1 . f DeffDt\ mm+1

= [F]m+Dt(kon[F]m[FH]m -^Mm+^[FH]m) (14) [FH]m+1 = [FH]m + Dt(kon[H]0[F]m - M^W - koff [FH]m) (15)

Metabolic Processes at Injection Sites Affecting Pharmacokinetics, Pharmacodynamics, and Metabolism of Protein and Peptide Therapeutics

Randall J. Mrsny

Department of Pharmacy and Pharmacology, University of Bath, Bath, U.K.

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