Prednisolone and Interleukin10

A pharmacodynamic interaction study between prednisolone and IL-10 was conducted by Chakraborty and Jusko (48). To determine the nature and intensity of interaction between these two compounds, the authors used isobolograms along with parametric competitive and noncompetitive interaction models. The isobolographic model indicated that the effect of prednisolone and IL-10 is additive in suppressing lymphocyte proliferation. The competitive interaction model revealed the interaction to be slightly synergistic, whereas the non-competitive interaction model indicated a small degree of antagonism. This study highlights the importance of different modeling methods and the outcome of these methods, which may be model dependent. Therefore, one should be cautious in the interpretation of data when using divergent models.

0 0

Post a comment